Skip to main content Skip to secondary navigation
Journal Article

The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model

Precision medicine models for personalizing achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behaviors is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and obesity - two top contributors to the global burden of disease and disability. To optimize treatments and address these burdens, behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings. Here, we present the conceptual framework and protocol for a novel study, "Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes (ENGAGE)". The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity. We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling. By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases.

View PDF

L.M. Williams
A. Pines
A.N. Goldstein-Piekarski
L.G. Rosas
M. Kullar
M.D. Sacchet
O. Gevaert
J.N. Bailenson
P.W. Lavori
P. Dagum
B. Wandell
C. Correa
W. Greenleaf
T. Suppes
L.M. Perry
J.M. Smyth
M.A. Lewis
E.M. Venditti
M. Snowden
J.M. Simmons
J. Ma
Journal Name
Behaviour Research and Therapy
Publication Date